Klinik Atölye

Akciğer nodülü ve kitlesi · Patoloji · Orta öncelik

Saf buzlu cam nodülü

Pure ground-glass nodule

Saf buzlu cam nodülü: yayımlanmış olgu görüntüsü, aksiyel kesit

4 adım

Görüntü: Wu FZ, Chen PA, Wu CC ve ark., “Semiquantative Visual Assessment of Sub-solid Pulmonary Nodules ≦3 cm in Differentiation of Lung Adenocarcinoma Spectrum.”, 2017, Figure 4. PMC5694004 · doi:10.1038/s41598-017-16042-9 · CC BY 4.0. Değişiklik: kırpıldı, yeniden boyutlandırıldı, odak işaretleri eklendi.

Özet

Saf buzlu cam nodülü, artmış parankim atenüasyonuna karşın içinden damar ve bronşların seçilebildiği fokal opasitedir. İnce kesit kontrastsız BT, lezyon niteliğini ve geçici inflamatuvar taklitçilerden ayrımını değerlendirmede temel yöntemdir. Kalıcı veya yoğunluğu artan odağı yalnız boyuta bakarak izlemek, adenokarsinom spektrumundaki değişimi kaçırabilir.

Faz ve pencere

Kontrastsız tanısal
İnce kesit akciğer algoritmasında fokal hafif atenüasyon artışı ve opasite içinden seçilebilen damar/bronşlar aranır; belirgin solid bileşen yoktur, rutin kontrast gerekmez.

Önerilen pencereler: Akciğer (G 1500 / M -600), Mediasten (G 350 / M 50).

BT bulguları

  • Normal parankime göre fokal hafif atenüasyon artışı vardır, ancak damar/bronş konturları izlenir.
  • İnce kesitlerde belirgin solid bileşen olmaması saf buzlu cam tanımını destekler.
  • Tek/çoklu oluşu, lob dağılımı, sınır ve plevraya uzaklık kaydedilir.
  • Seri incelemede çap artışının yanında yeni solid odak veya artan atenüasyon aranır.
  • Yamalı buzlu cam, sentrilobüler nodül veya konsolidasyon, geçici inflamasyonu düşündürür.

Ölçütler ve sınıflamalar

Subsolid nodülde ince kesit
İnce kesit BT'nin ölçüm doğruluğunu ve tekrarlanabilirliğini artırdığı bilinmektedir; kesit kalınlığının azaltılması küçük nodüllerde CT sayılarının daha doğru ve tekrarlanabilir olmasını sağlar.
Fleischner Society subsolid nodül yaklaşımı
Saf GGN ve part-solid nodül ayrı sınıflardır; tesadüfi bulgu rehberi tarama BT’si için kullanılmaz.
Lung-RADS v2022
Akciğer kanseri tarama BT’sinde ACR Lung-RADS v2022 kullanılır; kategori nodül boyutu ve solid bileşen özelliklerine göre belirlenir, tesadüfi nodülle karıştırılmaz.

Normalde

Normal parankimde pulmoner damarlar çevre akciğer havasına karşı net seçilir. GGN’de damarlar görünür kalırken çevre hava atenüasyonu artmıştır; posterior alt lobdaki bağımlı dansiteyi yerçekimine bağımlı olmayan parankim bölgeleriyle karşılaştır.

Normal BT ile kıyasla

Aynı bölgenin, kaynak veri setinde patoloji içermediği belirtilen bir BT incelemesini kesit kesit kaydırın; organ sınırlarını açarak anatomiyi hasta görüntüsüyle karşılaştırın. Küçük rastlantısal bulgular tümüyle dışlanmamıştır.

Kaynak: TotalSegmentator v2.01 veri seti (Wasserthal ve ark., Radiology: Artificial Intelligence 2023), CC BY 4.0, vaka s1278; organ sınırları veri setinin otomatik segmentasyonundan, birleştirilerek sadeleştirildi. Görüntüler 2,5 mm kesit aralığına yeniden örneklendi.

Ayırıcı tanı

Enfeksiyöz/inflamatuvar GGN
yamalı dağılım, sentrilobüler odak veya seri incelemede gerileme.
Bağımlı dansite
posterior ve yerçekimine bağlı dağılım gösterebilir.
Parsiyel hacim etkisi
küçük nodüllerde kalın kesit ölçüm doğruluğunu azaltabilir; komşu damarlar da hacim ölçüm hatasını artırabilir.
Fokal fibrozis
nodüler buzlu cam opasitenin benign taklitçilerinden biridir ve fibrotik alanlarda mimari distorsiyon görülebilir.

Tuzaklar

  • Tek BT görünümü AIS, MIA veya invaziv adenokarsinom alt tipini kesinleştirmez.
  • Kalın kesit küçük solid odağı saklayabilir; ince kesit ve mediasten penceresinde tekrar incele.
  • Dağılımını değerlendirmeden posterior bağımlı opasiteyi kalıcı nodüler GGN olarak kabul etme.

Kendini dene

  1. BT’de sınırlı, nodül biçimindeki hafif atenüasyon artışının içinden damarlar seçiliyor ve belirgin solid bileşen yok. Morfolojik sınıf hangisidir?

    Cevabı göster

    Saf buzlu cam nodülü. Buzlu camda atenüasyon artar, fakat damar/bronş izleri silinmez.

  2. Posterior alt lobda yamalı dansite yerçekimine bağımlı dağılım gösteriyor. En önemli taklitçi?

    Cevabı göster

    Bağımlı dansite. Posterior bağımlı opasite, bağımsız sınırlı kalıcı nodüler GGN’den farklıdır.

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Kaynaklar

Bu sayfadaki 34 cümle ve 2 quiz sorusu aşağıdaki kaynaklardan alıntılarla tek tek karşılaştırıldı; 6 cümle bu karşılaştırmada düzeltildi (2026-10-08).

  1. A narrative review of the clinical approach to subsolid pulmonary nodules.pubmed.ncbi.nlm.nih.gov
  2. Clinical and CT Features of Subsolid Pulmonary Nodules With Interval Growth: A Systematic Review and Meta-Analysis.pubmed.ncbi.nlm.nih.gov
  3. Predicting the Invasiveness of Pulmonary Adenocarcinomas in Pure Ground-Glass Nodules Using the Nodule Diameter: A Systematic Review, Meta-Analysis, and Validation in an Independent Cohort.pubmed.ncbi.nlm.nih.gov
  4. Low-dose CT screening among never-smokers with or without a family history of lung cancer in Taiwan: a prospective cohort study.pubmed.ncbi.nlm.nih.gov
  5. High resolution CT in differentiating minimally invasive component in early lung adenocarcinoma.pubmed.ncbi.nlm.nih.gov
  6. What is the appropriate operative strategy for radiologically solid tumours in subcentimetre lung cancer patients?†.pubmed.ncbi.nlm.nih.gov
  7. CT Characteristics for Predicting Invasiveness in Pulmonary Pure Ground-Glass Nodules.pubmed.ncbi.nlm.nih.gov
  8. Mucosa-associated lymphoid tissue lymphoma presenting as ground glass nodule.pubmed.ncbi.nlm.nih.gov
  9. Tertiary lymphoid structures in lung adenocarcinoma: characteristics and related factors.pubmed.ncbi.nlm.nih.gov
  10. Hybrid Clinical-Radiomics Model for Precisely Predicting the Invasiveness of Lung Adenocarcinoma Manifesting as Pure Ground-Glass Nodule.pubmed.ncbi.nlm.nih.gov
  11. Port-access thoracoscopic bisubsegmentectomy of right upper lobe posterior and anterior segments.pubmed.ncbi.nlm.nih.gov
  12. Qualitative CT Criterion for Subsolid Nodule Subclassification: Improving Interobserver Agreement and Pathologic Correlation in the Adenocarcinoma Spectrum.pubmed.ncbi.nlm.nih.gov
  13. Solitary Pulmonary Capillary Hemangioma of Adult Cases: Clinicopathologic Characteristics as an Unrecognized Entity.pubmed.ncbi.nlm.nih.gov
  14. Application Value of Spectral CT Imaging in Quantitative Analysis of Early Lung Adenocarcinoma.pubmed.ncbi.nlm.nih.gov
  15. Senescent SPP1 + macrophages remodel the tumor microenvironment and promote the progression of early-stage lung adenocarcinoma featured with mixed ground glass nodule.pubmed.ncbi.nlm.nih.gov
  16. Update in the evaluation of the solitary pulmonary nodule.pubmed.ncbi.nlm.nih.gov
  17. Ground-glass nodules of the lung in never-smokers and smokers: clinical and genetic insights.pubmed.ncbi.nlm.nih.gov
  18. Nodular ground-glass opacity at thin-section CT: histologic correlation and evaluation of change at follow-up.pubmed.ncbi.nlm.nih.gov
  19. Ground-glass opacity nodules: histopathology, imaging evaluation, and clinical implications.pubmed.ncbi.nlm.nih.gov
  20. Pulmonary Nodules.pubmed.ncbi.nlm.nih.gov
  21. Genomic characterisation of pulmonary subsolid nodules: mutational landscape and radiological features.pubmed.ncbi.nlm.nih.gov
  22. Intraoperative Transbronchial Metallic Coil Marking for Small Peripheral Pulmonary Lesions in a Hybrid Operation Room.pubmed.ncbi.nlm.nih.gov
  23. Feasibility study of a novel wireless localization technique using radiofrequency identification markers for small and deeply located lung lesions.pubmed.ncbi.nlm.nih.gov
  24. Clinical characteristics of resected solitary ground-glass opacities: Comparison between benign and malignant nodules.pubmed.ncbi.nlm.nih.gov
  25. Evaluation of ground glass nodules.pubmed.ncbi.nlm.nih.gov
  26. Prognostic Impact of the Histologic Lepidic Component in Pathologic Stage IA Adenocarcinoma.pubmed.ncbi.nlm.nih.gov
  27. Respiratory bronchiolitis-interstitial lung disease.pubmed.ncbi.nlm.nih.gov
  28. Eosinophilic bronchiolitis successfully treated with benralizumab.pubmed.ncbi.nlm.nih.gov
  29. Low-dose computed tomography in assessment of pulmonary abnormalities in children with febrile neutropenia suffering from malignant diseases.pubmed.ncbi.nlm.nih.gov
  30. Accuracy of the CT numbers of simulated lung nodules imaged with multi-detector CT scanners.pubmed.ncbi.nlm.nih.gov
  31. [Diagnostic imaging of lung cancer on multislice CT (MDCT)].pubmed.ncbi.nlm.nih.gov
  32. Pleural nodule identification in low-dose and thin-slice lung computed tomography.pubmed.ncbi.nlm.nih.gov
  33. Automatic detection and segmentation of ground glass opacity nodules.pubmed.ncbi.nlm.nih.gov
  34. Clinical Outcomes of Resected Pure Ground-Glass, Heterogeneous Ground-Glass, and Part-Solid Pulmonary Nodules.pubmed.ncbi.nlm.nih.gov
  35. Effect of blood vessels on measurement of nodule volume in a chest phantom.pubmed.ncbi.nlm.nih.gov
  36. Forensic pathological evaluation of postmortem pulmonary CT high-density areas in serial autopsy cases of sudden cardiac death.pubmed.ncbi.nlm.nih.gov
  37. Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017.pubmed.ncbi.nlm.nih.gov
  38. Updated Fleischner Society Guidelines for Managing Incidental Pulmonary Nodules: Common Questions and Challenging Scenarios.pubmed.ncbi.nlm.nih.gov
  39. Nodule characterization: subsolid nodules.pubmed.ncbi.nlm.nih.gov
  40. ACR Lung-RADS v2022: Assessment Categories and Management Recommendations.pubmed.ncbi.nlm.nih.gov
  41. ACR Lung-RADS v2022: Assessment Categories and Management Recommendations.pubmed.ncbi.nlm.nih.gov
  42. Lung-RADS v2022 Update.pubmed.ncbi.nlm.nih.gov
  43. Malignant Nodules Detected on Lung Cancer Screening CT: Yield of Short-Term Follow-Up CT in Showing Nodule Growth.pubmed.ncbi.nlm.nih.gov
  44. A Decision Analysis of Follow-up and Treatment Algorithms for Nonsolid Pulmonary Nodules.pubmed.ncbi.nlm.nih.gov
  45. Improved interobserver agreement on nodule type and Lung-RADS classification of subsolid nodules using computer-aided solid component measurement.pubmed.ncbi.nlm.nih.gov
  46. ANCA-associated vasculitis in idiopathic pulmonary fibrosis: A case report and brief review of the literature.pubmed.ncbi.nlm.nih.gov
  47. Role of serological rapid antibody test in the management of possible COVID-19 cases.pubmed.ncbi.nlm.nih.gov
  48. Para-aortic lymphadenopathy associated with adult COVID-19 multisystem inflammatory syndrome.pubmed.ncbi.nlm.nih.gov
  49. Prone position PET/CT is useful in reducing gravity-dependent opacity-related [ 18 F]fluorodeoxyglucose uptake.pubmed.ncbi.nlm.nih.gov
  50. Factors associated with gravity-dependent distribution on chest CT in elderly patients with community-acquired pneumonia: a retrospective observational study.pubmed.ncbi.nlm.nih.gov
  51. Efficacy of Near-Infrared Fluorescence Video-Assisted Thoracoscopic Surgery for Small Pulmonary Nodule Resection with Indocyanine Green Inhalation: A Randomized Clinical Trial.pubmed.ncbi.nlm.nih.gov
  52. Free-breathing dynamic contrast-enhanced magnetic resonance of interstitial lung fibrosis.pubmed.ncbi.nlm.nih.gov
  53. Diagnostic accuracy and image quality evaluation of ultrashort echo time MRI in the lungs.pubmed.ncbi.nlm.nih.gov
  54. A localization-independent approach for invisible and impalpable ground-glass opacity nodules detection in an in vitro lung specimen: two case reports.pubmed.ncbi.nlm.nih.gov
  55. Management of Ground-Glass Opacities in the Lung Cancer Spectrum.pubmed.ncbi.nlm.nih.gov
  56. Feasibility of lung imaging with a large field-of-view spectral photon-counting CT system.pubmed.ncbi.nlm.nih.gov
  57. Interobserver size measurement variability in part-solid lung adenocarcinoma using pre-operative computed tomography.pubmed.ncbi.nlm.nih.gov
  58. CT features and quantitative analysis of subsolid nodule lung adenocarcinoma for pathological classification prediction.pubmed.ncbi.nlm.nih.gov
  59. What every radiologist should know about idiopathic interstitial pneumonias.pubmed.ncbi.nlm.nih.gov
  60. The revised lung adenocarcinoma classification-an imaging guide.pubmed.ncbi.nlm.nih.gov
  61. Multidimensional biological characteristics of ground glass nodules.pubmed.ncbi.nlm.nih.gov
  62. Predicting Invasiveness of Lung Adenocarcinoma at Chest CT with Deep Learning Ternary Classification Models.pubmed.ncbi.nlm.nih.gov
  63. Impact of CT slice thickness reduction algorithm on AI-based lung nodule detection in chest CTs of colorectal cancer patients.pubmed.ncbi.nlm.nih.gov
  64. Deep learning-based super-resolution ultrashort echo time MRI for pulmonary nodule detection and longitudinal assessment in emphysema.pubmed.ncbi.nlm.nih.gov
  65. AI-accelerated 3D gradient echo versus ultrashort echo time MRI for lung nodule detection and measurement.pubmed.ncbi.nlm.nih.gov
  66. Diagnostic performance of commercial AI systems versus participating radiologists for pulmonary nodule detection in routine clinical practice.pubmed.ncbi.nlm.nih.gov
  67. Ultra-high spatial resolution at photon-counting computed tomography: technical insights and sustainable applications in cardiothoracic imaging.pubmed.ncbi.nlm.nih.gov
  68. Hypersensitive detection of single millimeter vascular emboli from adhesive in vivo.pubmed.ncbi.nlm.nih.gov
  69. Indolent Progression of a Persistent Positron Emission Tomography (PET)-Negative Ground-Glass Pulmonary Nodule to Pulmonary Adenocarcinoma Following Nine Years of Radiographic Surveillance: A Case Report.pubmed.ncbi.nlm.nih.gov
  70. Five Cases of Primary Pulmonary Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma With Atypical Image Findings and Literature Review: A Case Series.pubmed.ncbi.nlm.nih.gov
  71. Imaging-based development and validation of artificial intelligence models for lung adenocarcinoma precursor lesions and early lung adenocarcinoma presenting as pulmonary nodules.pubmed.ncbi.nlm.nih.gov
  72. Diagnostic Performance of 3.0-Tesla Magnetic Resonance Imaging for Pulmonary Nodules and Masses: A Comparative Cross-Sectional Study With Multidetector Computed Tomography.pubmed.ncbi.nlm.nih.gov
  73. CT-based interpretable delta-radiomics model for risk stratification of pulmonary ground-glass nodules: a multicentre study.pubmed.ncbi.nlm.nih.gov
  74. Clinicoradiologic features and evolutionary characteristics of pulmonary focal mucinous adenocarcinomas across different density patterns: a retrospective multi-center study.pubmed.ncbi.nlm.nih.gov
  75. Performance of multi-planar volume rendering versus maximum intensity projection and minimum intensity projection on pulmonary nodule detection.pubmed.ncbi.nlm.nih.gov
  76. AI driven hybrid convolutional and transformer based deep learning architecture for precise lung nodule classification.pubmed.ncbi.nlm.nih.gov
  77. Incidental Lung Lesions on the CT Component of Oncologic FDG PET/CT: A Pictorial Review of Interpretive Pitfalls and Diagnostic Clues.pubmed.ncbi.nlm.nih.gov
  78. Feasibility of Conventional Abdominal Ultrasound for Monitoring Tumor Size After Stereotactic Body Radiotherapy for Hepatocellular Carcinoma.pubmed.ncbi.nlm.nih.gov
  79. Imaging features of lung cancer with cystic airspaces: clinical utility, challenges, and perspectives.pubmed.ncbi.nlm.nih.gov
  80. Deep Learning-Based Slice Thickness Reduction for Computer-Aided Detection of Lung Nodules in Thick-Slice CT.pubmed.ncbi.nlm.nih.gov
  81. Geometric localization technique combined with modified inflation-deflation method identifies both GGO location and intersegmental planes in pulmonary segmentectomy.pubmed.ncbi.nlm.nih.gov
  82. Lung cancer associated with cystic airspaces: current progress and future perspectives.pubmed.ncbi.nlm.nih.gov
  83. Growth characteristics of early-stage (IA) lung adenocarcinoma and its value in predicting lymph node metastasis.pubmed.ncbi.nlm.nih.gov
  84. Lipoid Pneumonia: HRCT and MRI Spectrum, Diagnostic Pitfalls, and Imaging-Based Diagnostic Workflow.pubmed.ncbi.nlm.nih.gov
  85. Diffuse cystic lung diseases-a primer for radiologists.pubmed.ncbi.nlm.nih.gov
  86. Contrast-Enhanced CT of the Coelom in a Female Bald Eagle (<i>Haliaeetus leucocephalus</i>): Development of a Preliminary CT-Based Anatomical Segmentation Workflow.pubmed.ncbi.nlm.nih.gov
  87. Negative-pressure assistance for intraoperative cone-beam computed tomography localization in lung tumor resection: comparative study.pubmed.ncbi.nlm.nih.gov
  88. Comparative assessment of image quality and radiation dose: spectral purification computed tomography (Sn100kV) with adaptive iterative reconstruction for tuberculosis follow-up.pubmed.ncbi.nlm.nih.gov
  89. Case Report: Delayed appearance of the ablation margin after CT-guided microwave ablation of a solid pulmonary nodule.pubmed.ncbi.nlm.nih.gov
  90. A multimodal bronchoscopic approach for diagnosing peripheral ground-glass nodules using Cone-Beam computed tomography and cryobiopsy: a preliminary study.pubmed.ncbi.nlm.nih.gov
  91. Incidental pulmonary findings on CT in daily practice: the nodule and the interstitial lung abnormalities - what's old, what's new.pubmed.ncbi.nlm.nih.gov
  92. Invasive mucinous adenocarcinoma of the lung: integrating molecular landscape, imaging phenotypes, and translational therapeutic strategies.pubmed.ncbi.nlm.nih.gov

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